Molecular, Cellular, and Developmental Biology Professor & Chief Scientific Officer, BioFrontiers Institute at the University of Colorado, Boulder
Leslie Leinwand, Ph.D., is a Molecular, Cellular, and Developmental Biology (MCDB) Professor and the chief scientific officer of the BioFrontiers Institute at the University of Colorado, Boulder. The interests of Dr. Leinwand's laboratory are the genetics and molecular physiology of inherited diseases of the heart and how gender and diet modify the heart. Her laboratory's efforts are funded by multiple grants from the National Institutes of Health and her teaching is recognized by funding from the Howard Hughes Medical Institute's (HHMI) Professor Program. She is the principle investigator of the HHMI's Biological Sciences Initiative, which supports undergraduate research, K-12 outreach and educational programs for high school teachers. She was elected as a fellow of the American Association for the Advancement of Sciences and to the American Academy of Arts and Sciences. Previously, Dr. Leinwand served as a faculty member of the Albert Einstein College of Medicine. While at Albert Einstein, she was also the director of the Cardiovascular Research Center. She is a co-founder of the University of Colorado Cardiovascular Institute, Myogen, Inc., which was recently sold to Gilead Pharmaceuticals and Hiberna, Inc.
Dr. Leinwand holds a bachelor's degree from Cornell University and a Ph.D. from Yale University. She completed her postdoctoral training at Rockefeller University.
Professor of Genetics &Thomas W. Smith Professor of Medicine, Harvard Medical School and Brigham and Women's Hospital; Investigator, Howard Hughes Medical Institute
Christine (Kricket) Seidman, M.D., is a Professor of Genetics and the Thomas W. Smith Professor of Medicine at Harvard Medical School and Brigham and Women's Hospital. She is also an investigator of the Howard Hughes Medical Institute. She joined the staff at Brigham and Women's Hospital in 1987 and is currently the director of the Cardiovascular Genetics Center. Along with her husband Jonathan Seidman, Ph.D., Dr. Seidman has elucidated multiple genetic causes of human disorders affecting the heart and vasculature. The Seidmans' discoveries include the identification and demonstration of genetic mutations causing hypertrophic cardiomyopathy and dilated cardiomyopathy, as well as the first genetic cause of congenital heart malformations. In addition to recognition received jointly with her husband, Dr. Seidman's recent honors include Distinguished Scientist, American Heart Association; Distinguished Alumni Achievement Award, The George Washington University; The 21st Annual Glorney-Raisbeck Award; and the Jay and Jean Schottenstein Prize in Cardiovascular Science. She is a member of the Association of University Cardiologists and an elected member to the National Academy of Sciences.
Dr. Seidman holds an undergraduate degree from Harvard College and an M.D. from George Washington University School of Medicine. Dr. Seidman served as an intern and resident in internal medicine at John Hopkins Hospital and received subspecialty training in cardiology at the Massachusetts General Hospital.
Henrietta B. and Frederick H. Bugher Foundation Professor of Genetics, Harvard Medical School
Jonathan Seidman, Ph.D., is the Henrietta B. and Frederick H. Bugher Foundation Professor of Genetics at Harvard Medical School. He has been a member of the genetics department at Harvard Medical School since 1981. The Seidman Laboratory, which Dr. Seidman co-runs with his wife Christine Seidman, M.D., studies the genetic basis for human disease with a focus on heart disease. Investigations range from the discovery of genetic variants in rare and common cardiovascular phenotypes to elucidation of how genetic variations alter signaling mechanisms in model organisms, information that may be translated into novel therapeutic interventions in human patients. He has been recognized with a number of awards – several jointly with Seidman – including the Gill Heart Institute Award for Outstanding Contributions to Cardiovascular Research, the Lefoulon-Delalande Foundation Grand Prix for Science and the Katz Prize for Cardiovascular Research awarded by Columbia University School of Medicine. Dr. Seidman is an elected member of the National Academy of Science and the Institutes of Medicine, as well as a member of The Genetics Society of America and the American Society of Human Genetics.
Dr. Seidman holds a bachelor's degree from Harvard University and a Ph.D. from the University of Wisconsin-Madison. He completed his postdoctoral studies at the National Institute of Child Health and Human Development.
Douglass M. and Nola Leishman Professor of Cardiovascular Disease, Stanford University
James Spudich, Ph.D., serves as the Douglass M. and Nola Leishman Professor of Cardiovascular Disease in the Department of Biochemistry at Stanford University. His laboratory studies how enzymes use specific structural elements to carry out their exquisite roles. Specifically, his research has focused on the myosin family of enzymes. Over the last 35 years, Dr. Spudich and scientists in his lab have used an interdisciplinary and multifaceted approach to elucidate the molecular basis of energy transduction by the myosin family of molecular motors. Dr. Spudich also serves as a visiting faculty member at the National Center for Biological Sciences of the Tata Institute of Fundamental Research in Bangalore, India. Dr. Spudich is a co-founder and former director of Cytokinetics and the Stanford University Bio-X program. He currently serves as the chair of the International Affairs Committee for the American Society for Cell Biology, and has previously served as president of the organization. Dr. Spudich has been recognized with numerous honors for his achievements in the field, including the American Heart Association Basic Research Prize and the 2012 Lasker Basic Medical Research Award. He is an elected member of the National Academy of Sciences, American Academy of Arts and Sciences and the American Association for the Advancement of Science. He has authored more than 190 peer-reviewed publications.
Dr. Spudich holds a B.S. in chemistry from the University of Illinois at Champaign-Urbana and Ph.D. in biochemistry from Stanford University. He completed his postdoctoral work in genetics and structural biology at Stanford University and the MRC Laboratory of Molecular Biology in Cambridge, England.